Anti-HBc determinations can be used to monitor the progress of hepatitis B viral infection. Anti-HBc is found in serum shortly after the appearance of Hepatitis B Surface Antigen (HBsAg) in acute hepatitis B infections. It will persist after the disappearance of HBsAg and before the appearance of detectable antibody to HBsAg (anti-HBs).
In the absence of information about any other hepatitis B virus (HBV) markers, it must be considered that an individual with detectable levels of anti-HBc may be actively infected with HBV or that the infection may have resolved, leaving the person immune. Anti-HBc may be the only serological marker of hepatitis B viral infection and potentially infectious blood. The presence of anti-HBc does not differentiate between acute or chronic hepatitis B infections.
Preparation of Patient: There is no special physical preparation for the test.